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Anti-Bcl2 modifying factor抗体

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产品名称: Anti-Bcl2 modifying factor抗体
产品型号: Bcl2蛋白修饰因子抗体
产品展商: 科研抗体
产品文档: 无相关文档

简单介绍

Anti-Bcl2 modifying factor抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-Bcl2 modifying factor抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。


Anti-Bcl2 modifying factor抗体  的详细介绍
Rabbit  Anti-Bcl2 modifying factor
Cat. Number:
YB7587R
Quantity size:
0.1ml
Concentration:
Anti-Bcl2 modifying factor抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The BH3-only proteins, which include Blk, Bad, Bik, Hrk, BID, Bim, NOXA, PUMA and Bmf, are proapoptotic members of the Bcl-2 family. Bcl-2 modifying factor (Bmf) is a BH3-only protein that binds prosurvival Bcl-2 family members to initiate apoptosis. Bmf is sequestered to Myosin V motors on Actin in the cytoskeleton Anti-Bcl2 modifying factor抗体by associating with Dynein light chain 2 (DLC2) homodimers. If the cell undergoes loss of attachment (anoikis), the cytoskeleton is disrupted and Bmf is released from DLC2. Bmf then translocates to the mitochondria, where Bcl-2 (an anti-apoptotic family member) is sequestered. The BH3 domain of Bmf facilitates binding to a hydrophobic groove on the surface of Bcl-2. Binding results in a caspase cascade leading to apoptosis. Bmf is widely expressed in tissues such as pancreas, liver and kidney, and in hematopoietic tissues. The gene encoding Bmf maps to chromosome 15q14.
Also known as:
Anti-Bcl2 modifying factor抗体Bcl 2 modifying factor; Bcl-2-modifying factor; Bcl2 modifying factor; Bmf; BMF_HUMAN; FLJ00065.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Anti-Bcl2 modifying factor抗体Mouse, Rat, Dog, Cow, Horse, Rabbit, .
Immunogen: KLH conjugated synthetic peptide derived from human Bcl2 modifying factor (54-88aa).
Predicted Molecular Weight: 20kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
Anti-Bcl2 modifying factor抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
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