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Anti-Phospho-BRCA1 (Ser1189)抗体

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产品名称: Anti-Phospho-BRCA1 (Ser1189)抗体
产品型号: 磷酸化乳腺癌易感基因1抗体
产品展商: 科研抗体
产品文档: 无相关文档

简单介绍

Anti-Phospho-BRCA1 (Ser1189)抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-Phospho-BRCA1 (Ser1189)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。


Anti-Phospho-BRCA1 (Ser1189)抗体  的详细介绍
Rabbit  Anti-Phospho-BRCA1 (Ser1189)
Cat. Number:
YB5221R
Quantity size:
0.1ml
Concentration:
Anti-Phospho-BRCA1 (Ser1189)抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, Anti-Phospho-BRCA1 (Ser1189)抗体also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Also known as:
Anti-Phospho-BRCA1 (Ser1189)抗体BRCA1 (phospho Ser1189); BRCA1 (phospho S1189); p-BRCA1 (phospho S1189); BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, .
Immunogen:Anti-Phospho-BRCA1 (Ser1189)抗体 KLH conjugated Synthesised phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1189.
Predicted Molecular Weight: 205kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
Anti-Phospho-BRCA1 (Ser1189)抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
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