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Anti-Phospho-BTK (Tyr223)抗体

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产品名称: Anti-Phospho-BTK (Tyr223)抗体
产品型号: 磷酸化酪氨酸蛋白激酶BTK抗体
产品展商: 科研抗体
产品文档: 无相关文档

简单介绍

Anti-Phospho-BTK (Tyr223)抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-Phospho-BTK (Tyr223)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。


Anti-Phospho-BTK (Tyr223)抗体  的详细介绍
Rabbit  Anti-Phospho-BTK (Tyr223)
Cat. Number:
YB3069R
Quantity size:
0.1ml
Concentration:
Anti-Phospho-BTK (Tyr223)抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation ted by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. Anti-Phospho-BTK (Tyr223)抗体The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
Also known as:
Anti-Phospho-BTK (Tyr223)抗体BTK (phospho Y223); p-BTK (phospho Y223); Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Anti-Phospho-BTK (Tyr223)抗体Mouse, Rat, Pig, Cow, Horse, Rabbit, .
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human Btk around the phosphorylation site of Tyr223 [AL(p-Y)DY].
Predicted Molecular Weight: 76kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
Anti-Phospho-BTK (Tyr223)抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
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