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Anti-Phospho-Bad (Ser136)抗体

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产品名称: Anti-Phospho-Bad (Ser136)抗体
产品型号: 磷酸化相关死亡促进因子抗体
产品展商: 科研抗体
产品文档: 无相关文档

简单介绍

Anti-Phospho-Bad (Ser136)抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-Phospho-Bad (Ser136)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。


Anti-Phospho-Bad (Ser136)抗体  的详细介绍
Rabbit  Anti-Phospho-Bad (Ser136)
Cat. Number:
YB3056R
Quantity size:
0.1ml
Concentration:
Anti-Phospho-Bad (Ser136)抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory Anti-Phospho-Bad (Ser136)抗体effect of growth factor on Bad-ted apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Also known as:
Anti-Phospho-Bad (Ser136)抗体Bad (phospho S136); BAD (Phospho-Ser136); p-Bad (S136); p-BAD (Ser136); p-Bad (phospho S136); BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .
Immunogen: KLH conjugated Synthesised phosphopeptide derived from mouse BAD around the phosphorylation site of Ser136.
Predicted Molecular Weight: 18kDa.
Storage:
Shipped at 4℃, Anti-Phospho-Bad (Ser136)抗体Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
Anti-Phospho-Bad (Ser136)抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.Rattus norvegicus (Rat)
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