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Anti-phospho-Ataxin-1 (Ser238)抗体

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产品名称: Anti-phospho-Ataxin-1 (Ser238)抗体
产品型号: 磷酸化失调症蛋白1抗体
产品展商: 科研抗体
产品文档: 无相关文档

简单介绍

Anti-phospho-Ataxin-1 (Ser238)抗体供应商为您提供抗体的售前、售中、售后服务,现货供应,保证实验结果,无效可以免费退换,广泛应用于IHC、WB、 IF、IP、ELISA,质量保证,另外本公司生产经营各种单克隆抗体、多克隆抗体,标记二抗、**印迹常用试剂、**组化常用试剂,Anti-phospho-Ataxin-1 (Ser238)抗体用于**组化实验,WB实验,相应的标记抗体有HRP标记抗体,FITC标记,BIO等。


Anti-phospho-Ataxin-1 (Ser238)抗体  的详细介绍
Rabbit  Anti-phospho-Ataxin-1 (Ser238)
Cat. Number:
YB8597R
Quantity size:
0.1ml
Concentration:
Anti-phospho-Ataxin-1 (Ser238)抗体1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. Anti-phospho-Ataxin-1 (Ser238)抗体ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1).
Also known as:
Anti-phospho-Ataxin-1 (Ser238)抗体Ataxin-1 (phospho-Ser238); Ataxin-1 (phospho S238); ATXN1; ATX1; D6S504E; SCA1; Ataxin-1; Spinocerebellar ataxia type 1; ATX1_HUMAN.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Anti-phospho-Ataxin-1 (Ser238)抗体Dog, Horse, Rabbit, Guinea Pig, .
Immunogen: KLH conjugated synthesised phosphopeptide derived from human ATXN1 around the phosphorylation site of Ser238.
Predicted Molecular Weight: 90kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
Anti-phospho-Ataxin-1 (Ser238)抗体WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
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